- Utilize bedside and invasive monitoring to assess the source of drug-induced shock
- Vasoplegia
- Impaired contractility
- Both
- Tailor resuscitation based on the individual patient’s altered physiology
- Impaired contractility: HDI
- Vasoplegia: calcium salts, levophed, phenylephrine, epinephrine, vasopressin, methylene blue
- Bradycardia: calcium salts, glucagon, pacing
- Wide-complex QRS (sodium channel blockade): sodium bicarbonate therapy
- Maximize pharmacological management of drug-induced shock
- May require large doses of resuscitation drugs; much larger than standard ACLS doses
- For refractory shock
- Lipid rescue for lipophilic drugs
- ECMO
- Utilize Medical Toxicology experts for assistance with drug-induced shock resuscitation