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High Risk ACS without diagnostic ST-Segment Elevation - Dr. L. Littmann

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Posterolateral MI
  • Acute thrombotic LCX occlusion – it is a STEMI
  • Diagnostic criteria
    • presentation with acute chest pain
    • ST depression in the anterior chest leads which may be due to anterior ischemia, posterior STEMI or RVH with strain
    • posterior STEMI is frequently accompanied by subtle Q waves, subtle ST elevation or the “wishbone sign” in the inferior and/or lateral leads
  • It is a STEMI but ST elevation may not be seen in the 12-lead ECG (“STEMI without  STE”)
  • Place ECG leads to the back (V7-V8-V9)
  • Any ST elevation in the posterior leads warrants immediate cath/reperfusion
 

Dressler - de Winter sign
  • Acute thrombotic proximal LAD occlusion – a STEMI equivalent
    • in 98% of cases of acute LAD occlusion: there is frank electrocardiographic STEMI
    • in 2% of cases of acute LAD occlusion: Dressler - de Winter sign
  • Diagnostic criteria
    • presentation with acute chest pain
    • very tall “hyperacute” T waves in the chest leads
    • usually accompanied by upsloping ST depression (ST depressed at the J point)
    • patients are frequently young males
    • chest pain to the “de Winter” ECG presentation is usually within 30-120 minutes
  • Imminent risk of extensive anterior STEMI
  • The de Winter sign warrants immediate cath/reperfusion
 

aVR sign
  • 80% specific for tight left main coronary artery stenosis – high risk of large STEMI
  • Diagnostic criteria
    • presentation with acute chest pain
    • diffuse ST-segment depression
    • ST elevation ³1 mm in aVR
  • High but not necessarily imminent risk of STEMI, usually extensive, frequently lethal (“widow-maker artery”)
  • Urgent cath/reperfusion is indicated (but not necessarily immediate cath)
 

Wellens sign, Wellens syndrome
  • Suggestive of tight proximal LAD stenosis – high risk of subsequent anterior STEMI
  • Diagnostic criteria
    • presentation with chest pain
    • biphasic (positive-negative) T waves in the anterior chest leads (type A – 25%) and/or
    • deep symmetrical negative T waves in the chest leads (type B – 75%)
    • no abnormal Q waves; normal R-wave progression in the chest leads
    • T-wave abnormalities can be present even in the pain-free state
    • no or only subtle troponin elevation
  • If undetected/untreated, high risk of subsequent STEMI, usually days/weeks later
  • In typical Wellens syndrome: cardiac cath without prior stress testing is indicated


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