- Warfarin can cause two dermatologic syndromes: Warfarin Skin Necrosis (thrombotic) and Purple Toe Syndrome (embolic)
- Cutaneous Anthrax starts as a small, painless papule that transitions to a vesicle then necrotic ulcer with surrounding edema. It is most common on the head, neck, forearms and hands.
- Blistering Agents are sulfur mustard and lewisite. Sulfur mustard has no pain initially while lewisite there is immediate pain.
- Chronic arsenic toxicity is associated with hyperkeratosis, skin pigmentation changes, Blackfoot's disease, lung, bladder and skin cancer.
- Mee's line can be seen with arsenic, thallium, heavy metals, renal failure, chemotherapy and sepsis.
- Inorganic mercury has been associated with a skin finding called Pink's disease or acrodynia.
- Basophillic stipling and Burton's lines can be seen with lead toxicity.
- The most common cause is allergic dermatitis is nickel.
- Levamisole has been a known contaminant of cocaine causing skin necrosis.
- To make the diagnosis of DRESS there must be: rash, fever, and end organ dysfunction.
- To differentiate between carotenemia vs jaundice, carotenemia can be wiped off with an alcohol wipe and it does not involve the sclera.
- Red man syndrome is most commonly seen with vancomycin and rifampin.
