High ETOH concentration is protective against methanol and ethylene glycol (metabolized slower as ethanol is metabolized first)
Ethylene Glycol
- the metabolites, not ethylene glycol, cause acidosis and toxicity
- ethylene glycol itself, not the toxic metabolites, cause increased osmolal gap
- Fomepizole recommended
Methanol
- Permanent blindness has occurred after ingestion of approximately 1 teaspoon of methanol
- Fomepizole recommended
Isopropyl Alcohol
- Since the parent compound causes toxicity, not the metabolite (acetone), fomepizole not indicated.
- Urine ketones will be positive (Ketosis without acidosis)
Ethylene Glycol
- the metabolites, not ethylene glycol, cause acidosis and toxicity
- ethylene glycol itself, not the toxic metabolites, cause increased osmolal gap
- Fomepizole recommended
Methanol
- Permanent blindness has occurred after ingestion of approximately 1 teaspoon of methanol
- Fomepizole recommended
Isopropyl Alcohol
- Since the parent compound causes toxicity, not the metabolite (acetone), fomepizole not indicated.
- Urine ketones will be positive (Ketosis without acidosis)
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